CGD Heredity

What is CGD?

Chronic granulomatous disease (CGD) is a genetic disorder in which white blood cells called phagocytes are unable to kill certain types of bacteria and fungi. People with CGD are constantly at risk of developing bacterial and fungal diseases that can be life-threatening.

Causes of CGD

CGD is caused by defects in an enzyme, NADPH Oxidase, which is essential for proper function of the immune system. These defects are linked to any one of five different genes that are inherited via the X chromosome.


The immune system of a person with CGD does not work properly, leaving the body prone to bacterial and fungal infections. A person with CGD will oftentimes show signs of immunodeficiency at a very young age. Symptoms include, but are not limited to:

  • Granulomas (small areas of tissue inflammation), often located in the gastrointestinal tract
  • Abscesses (collections of puss) in the lungs, liver, spleen, bones, or skin
  • Swollen lymph nodes, or lymphadenitis
  • Continuous diarrhea
  • Persistent runny nose


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