CGD ASsociation of America
CGD ASsociation of America
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    • Home
    • Ways to Give
    • About Us
      • Who We Are
      • Partners and Sponsors
      • Mission & Accomplishments
      • Blog & E-Newsletter
    • Living with CGD
      • What is CGD?
      • Diagnosing CGD
      • Managing CGD
      • Treatments & Providers
      • X-linked CGD Carriers
      • For Clinicians
    • Getting Help & Support
      • CGDAA Zoom Calls
      • Financial Assistance
      • PC's for People
      • CGDAA Events
      • Carrier Connection
    • Contact
  • Home
  • Ways to Give
  • About Us
    • Who We Are
    • Partners and Sponsors
    • Mission & Accomplishments
    • Blog & E-Newsletter
  • Living with CGD
    • What is CGD?
    • Diagnosing CGD
    • Managing CGD
    • Treatments & Providers
    • X-linked CGD Carriers
    • For Clinicians
  • Getting Help & Support
    • CGDAA Zoom Calls
    • Financial Assistance
    • PC's for People
    • CGDAA Events
    • Carrier Connection
  • Contact

Chronic Granulomatous Disease Management

Avoiding infection in patients with CGD involves a combination strategy that typically includes prophylactic antibacterial agents, antifungal agents, and immunomodulation via interferon-gamma (IFN-γ) therapy (CGD prophylaxis) and avoidance of exposure to bacteria and fungi. Bacteria and fungi exposures are prevalent in daily life, but there are measures one can take to reduce exposure risk. People with CGD should avoid dirt, construction areas, caves, grass cuttings, decaying leaves, dust, garden mulch, fresh water (lakes, ponds, rivers), jacuzzis/hot tubs, and potting soil.

Managing CGD

Steroids

Antibiotics and Anti-Fungals

Antibiotics and Anti-Fungals

Steroids, such as prednisone or methylprednisolone, is an important part of  managing CGD (Chronic Granulomatous Disease). While steroid medications are useful for controlling inflammation, close monitoring for high blood pressure or high sugar levels is needed.  

Antibiotics and Anti-Fungals

Antibiotics and Anti-Fungals

Antibiotics and Anti-Fungals

For  Chronic Granulomatous Disease management, antibiotics are the first line of defense against bacterial infections. Commonly prescribed medications include Co-Trimoxazole or Septra, both of which contain trimethoprim and sulfamethoxazole. Infections for those with CGD are commonly triggered by bacteria in the environment so building a protective “wall” is imperative. 


Antifungal medications are another component of managing CGD. Antifungal medication, such as itraconazole, is used to prevent and reduce the amount of fungal infections,


Patients should be aware of and discuss any side effects of antibacterial and antifungal medications with their healthcare provider. 

Interferon-gamma injections

Antibiotics and Anti-Fungals

Interferon-gamma injections

Interferon gamma injections, such as Actimmune, can be prescribed for Chronic Granulomatous Disease management as a way to lower the frequency and severity of serious infections. 

Reducing Exposures for CGD

Bacteria and fungi exposures are prevalent in daily life but there are measures one can take to avoid exposure and reduce risk. 


  • Swimming: Swimming should occur in well-chlorinated pools. 
  • Yard waste: People with CGD should avoid dirt, grass cuttings, decaying leaves, garden mulch, and potting soil.
  • Housework: Individuals with CGD should avoid cleaning dusty areas.

CGD Association of America

2005 Palmer Ave, #197, Larchmont, NY 10538

(917) 309-3489

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The contents of the CGD Association of America  site, such as text, graphics, images, and other material contained on the CGDAA Site (“Content”) are for informational purposes only. The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding CGD or any medical condition.