Avoiding infection in patients with CGD involves a combination strategy that typically includes prophylactic antibacterial agents, antifungal agents, and immunomodulation via interferon-gamma (IFN-γ) therapy (CGD prophylaxis) and avoidance of exposure to bacteria and fungi. Bacteria and fungi exposures are prevalent in daily life, but there are measures one can take to reduce exposure risk. People with CGD should avoid dirt, construction areas, caves, grass cuttings, decaying leaves, dust, garden mulch, fresh water (lakes, ponds, rivers), jacuzzis/hot tubs, and potting soil.
Steroids, such as prednisone or methylprednisolone, is an important part of managing CGD (Chronic Granulomatous Disease). While steroid medications are useful for controlling inflammation, close monitoring for high blood pressure or high sugar levels is needed.
For Chronic Granulomatous Disease management, antibiotics are the first line of defense against bacterial infections. Commonly prescribed medications include Co-Trimoxazole or Septra, both of which contain trimethoprim and sulfamethoxazole. Infections for those with CGD are commonly triggered by bacteria in the environment so building a protective “wall” is imperative.
Antifungal medications are another component of managing CGD. Antifungal medication, such as itraconazole, is used to prevent and reduce the amount of fungal infections,
Patients should be aware of and discuss any side effects of antibacterial and antifungal medications with their healthcare provider.
Interferon gamma injections, such as Actimmune, can be prescribed for Chronic Granulomatous Disease management as a way to lower the frequency and severity of serious infections.
Bacteria and fungi exposures are prevalent in daily life but there are measures one can take to avoid exposure and reduce risk.
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