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CGD ASsociation of America
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  • Home
  • Ways to Give
  • Living with CGD
    • What is CGD?
    • Diagnosing CGD
    • Managing CGD
    • Treatments & Providers
    • For Clinicians
  • X-Linked Carriers
    • X-linked CGD Carriers
    • Carrier Connection
  • About Us
    • Who We Are
    • Partners and Sponsors
    • Mission & Accomplishments
    • Blog & E-Newsletter
    • Press Room
  • Resources & Support
    • CGDAA Zoom Calls
    • Financial Assistance
    • PC's for People
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What is Chronic Granulomatous Disease (CGD)?

Chronic Granulomatous Disease (CGD) is a rare, inherited genetic disorder that prevents the immune system from fighting specific types of bacteria or fungus infections. In CGD, white blood cells (phagocytes or neutrophils) are unable to make hydrogen peroxide to kill certain types of bacteria and fungi. Any of the 5 components of the NADPH complex experiencing a defect or any of the genes that encode for them results in CGD.


Genetically there are six types of Chronic Granulomatous Disease (CGD).

  • The most common type is X-linked CGD in North America, resulting in defects from gp91phox protein and affects about ⅔ of (male) patients. Mothers often pass this type of CGD on to their sons, so there are also female carriers who can be affected by their carrier status. 
  • Autosomal recessive CGD due to defects in the p47phox protein affects about 20% of CGD patients in North America, and up to 25% of patients worldwide. 
  • The sub-types of autosomal recessive CGD include:
    • NCF2 due to the p67phox protein that affects 7% of CGD patients
    • CYBA due to the p22phox protein that affects 7% of CGD patients
    • NCF4 due to the p40phox protein that affects less than 1% of CGD patients
    • CYBC1, EROS with few persons

Symptoms of Chronic Granulomatous Disease (CGD)

The immune system of a patient with CGD does not work properly, leaving the body prone to bacterial and fungal infections, such as staphylococcus aureus, serratia marcescens, burkholderia cepacia, nocardia species, and organisms from the aspergillus species. 


Patients with CGD are highly prone to life-threatening infections from these organisms in the lungs (pneumonias), lymph nodes, liver or bones. CGD can also cause excessive inflammation and autoimmune problems, particularly inflammatory bowel disease (CGD colitis).


However, response to viral infections is normal in patients with CGD. Chronic Granulomatous Disease may involve any organ system or tissue of the body, but infections are usually found in the skin, lungs, liver, lymph nodes, gastrointestinal tract, bones, and occasionally the brain. Wounds may also have trouble healing and an inflammatory condition known as granuloma may develop. Pneumonia caused by a fungus such as aspergillus is a red flag for CGD. Infection by normally non-pathogenic bacteria is also a red flag for CGD. 


A person with CGD will often show signs of an immunodeficiency at a very young age. Symptoms include, but are not limited to:

  • Granulomas (small areas of tissue inflammation), often located in the lung or gastrointestinal tract (which can cause chronic inflammatory bowel disease that closely resembles Crohn’s Disease or ulcerative colitis) 
  • Abscesses (collections of pus) in the lungs, liver, spleen, bones, or skin
  • Swollen lymph nodes or lymphadenitis
  • Continuous diarrhea, bloody diarrhea, or abdominal pain 
  • Prolonged or “yo-yo” fevers with no clear indication as to origin 
  • Frequent respiratory and skin infections as well as severe acne


Gastrointestinal inflammation disease affects about 88% of CGD patients in some form or another while lung inflammation affects around 26% of patients.

What is CGD? (pdf)

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Learn More About CGD

Diagnosing Chronic Granulomatous Disease (CGD)Managing Chronic Granulomatous Disease (CGD)Treatments for Chronic Granulomatous Disease (CGD)Referring Patients With CDG To Specialists/PhysciansCARRIERS OF X-LINKED CGD

Other Trusted Sources for FAQ's About Chronic Granulomatous Disease (CGD)

National Institutes of Health        Living with CGD (IDF)        CGD Society

CGD Association of America

3300 S. Dixie Hwy, Ste. 1-266, West Palm Beach, FL, 33405

+1 (689) 214-1351

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The contents of the CGD Association of America  site, such as text, graphics, images, and other material contained on the CGDAA Site (“Content”) are for informational purposes only. The Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding CGD or any medical condition.