Chronic Granulomatous Disease (CGD) is a rare, inherited genetic disorder that prevents the immune system from fighting specific types of bacteria or fungus infections. In CGD, white blood cells (phagocytes or neutrophils) are unable to make hydrogen peroxide to kill certain types of bacteria and fungi. Patients with CGD are highly prone to infections with these organisms in the lungs (pneumonias), lymph nodes, liver or bones. These infections can be life-threatening. CGD can also cause excessive inflammation and autoimmune problems, particularly inflammatory bowel disease.
